GENETIC TESTING FOR DIAGNOSIS OF PROGRESSIVE CARDIAC CONDUCTION DISEASE
نویسندگان
چکیده
منابع مشابه
Genetic determinants of cardiac (electric) conduction.
Sotoodehinia et al 1 investigated the role of common genetic variations (single nucleotide polymorphisms; SNPs) in determining QRS duration. The authors performed a meta-analysis of 14 genome-wide association studies of QRS duration in a total of 40 407 individuals (after adjustment for clinical variables) using a cut off of P 5 10 . The discovery phase was followed by a validation study consis...
متن کاملRapidly Progressive Cardiac Manifestation of Behçet's Disease Involving Conduction System and Aortic Valve
Cardiac conduction system impairment is a rare clinical manifestation of Behçet's disease. We report a patient who showed 1st degree atrioventricular block at first presentation, and showed aggravated finding of 3rd degree atrioventricular block on five months later. His cardiac manifestation finally developed to acute severe aortic regurgitation on six months later from his first cardiac manif...
متن کاملFamilial progressive cardiac conduction disorder and multiple exostoses.
Familial cardiac conduction disorder of a progressive nature has been reported in adult and paediatric patients. An underlying cardiomyopathy was found in most of these patients, either of hypertrophic, restrictive or dilated variety. Systemic diseases like juvenile rheumatoid arthritis and other collagen disorders and familial dysautonomia infrequently have associated conduction abnormalities....
متن کاملA complex double deletion in LMNA underlies progressive cardiac conduction disease, atrial arrhythmias, and sudden death.
BACKGROUND Cardiac conduction disease is a clinically and genetically heterogeneous disorder characterized by defects in electrical impulse generation and conduction and is associated with sudden cardiac death. METHODS AND RESULTS We studied a 4-generation family with autosomal dominant progressive cardiac conduction disease, including atrioventricular conduction block and sinus bradycardia, ...
متن کاملSodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease.
Some mutations of the sodium channel gene Na(V1.5) are multifunctional, causing combinations of LQTS, Brugada syndrome and progressive cardiac conduction system disease (PCCD). The combination of Brugada syndrome and PCCD is uncommon, although they both result from a reduction in the sodium current. We hypothesize that slow conduction is sufficient to cause S-T segment elevation and undertook a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2017
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(17)35672-3